SAM-e

SAM-e is a compound that's made naturally in the body and plays an important role in normal bodily function. The brain synthesizes SAM-e, or s-adenosylmethionine, from methionine, an essential amino acid that plays an important role in the growth of new blood vessels, and adenosine triphosphate, an energy-producing compound that acts as a source of fuel within our cells. It is made naturally in the body. SAM-e operates as a building block for an antidepressant action, potentially relieves osteoarthritis, helps Improve symptoms of fibromyalgia and supports liver function.

SAM-e increases the turnover of serotonin and may increase levels of dopamine and norepinephrine. It’s been shown to exhibit anti-inflammatory and analgesic effects and is often used to relieve pain while improving physical function.

A recommended dosage is 400 to 1,600 milligrams a day, taken on an empty stomach. Lower doses (under 800 milligrams) should be taken once a day, a half hour before the morning meal; higher doses should be split, taking the second a half hour before lunch. Starting patients with 200 mg 30 minutes before breakfast and 30 minutes before lunch minimizes the overstimulation and insomnia which some patients report in the first few weeks. This can be switched to 400 mg before breakfast after a few weeks.” Patients typically notice improvement in energy within two weeks.

SAM-e can be used alone or in conjunction with other antidepressants. Since its side effects are less than those of many antidepressants, SAM-e is better tolerated by many people: It works more rapidly and does not cause weight gain, sexual dysfunction, sedation, or cognitive interference. Contraindicated when taking MAOI antidepressant medications. Contraindicated in cases of bipolar disorder unless under close medical supervision as it may promote the manic phase. Contraindicated in Parkinson’s disease as it may aggravate some symptoms. Possible side effects include gastrointestinal upsets: nausea, vomiting, diarrhoea, indigestion. Anxiety, headache, insomnia, and allergies may also be experienced.